Simons Foundation/Flatiron Institute, Center for Computational Biology

Position ID:

3497-FRFBM [#27266]

Position Title:

Flatiron Research Fellow, Biophysical Modeling, Center for Computational Biology

Position Location:

New York, New York 10010, United States of America

Appl Deadline:

none (posted 2025/10/06)

Position Description:

Flatiron Research Fellow, Biophysical Modeling, Center for Computational Biology

Flatiron Institute - Simons Foundation

Location
162 5th Avenue, NY, NY 10010

Open Date
Sep 16, 2025

The Center for Computational Biology (CCB) of the Simons Foundation's Flatiron Institute is actively seeking enthusiastic, full-time post-doctoral Flatiron Research Fellows to join its
Biophysical Modeling Group in 2026.

The goal at CCB is to advance the understanding of fundamental and historically challenging biological processes by developing theory, innovative modeling tools for large-scale biophysical simulations, and computational frameworks for analyzing increasingly large and complex experimental datasets. Living systems are built hierarchically; as such, CCB's research activities span several scales of biological organization, bridging the gap between microscopic detail and large-scale behaviors, and providing natural continuity between our groups' efforts. CCB currently comprises more than 45 research and data scientists at career stages from recent Ph.D. graduates through senior scientists, as well as visiting scientists, guest researchers, graduate students, interns, and administrative support staff. For a full description of CCB research areas and scientific staff, please see our website.

The Biophysical Modeling group focuses on the modeling and simulation of complex systems that arise in biology and soft condensed matter physics. Areas of interest include the dynamics of complex and active materials, and aspects of collective behavior and self-organization in both natural systems (e.g., inside the cell) and synthetic ones. Ongoing projects focus on understanding the organization and dynamics of the nucleus, the structure and assembly of spindles, the positioning and transport of cellular organelles, and fluid-structure problems in biology. To address these, often in close collaboration with experimental collaborators, we build numerical and theoretical models from the ground up, revealing how the known mechanics of individual components give rise to collective behavior. Many such phenomena occur only within dense, highly interacting systems, inaccessible to standard techniques. To probe such regimes requires the development of fast and scalable algorithms for many-component systems, and of coarse-grained models that can be analyzed and simulated.

Strong applicants with backgrounds in applied and computational mathematics, biophysics, engineering, statistical inference, and related fields are particularly encouraged to apply.

POSITION DESCRIPTION
Flatiron Research Fellows in CCB are individuals at the postdoctoral level with backgrounds in one or more of the following areas: applied mathematics, statistics, computational biology, biophysics, computer science, engineering, mathematical physics, or related disciplines.

Fellows are expected to carry out an active research program that can be independently directed and/or involve substantial collaboration with other members of CCB or the Flatiron Institute. In addition to their research, Fellows help build the rich scientific community at CCB and the Flatiron Institute by participating in seminars, colloquia, and group meetings; developing their software, mathematical and computational expertise through internal education opportunities; and sharing their knowledge through scientific publications, presentations, and/or software releases, with the financial support of the Institute. Fellows have access to the Flatiron Institute's powerful scientific computing resources.

Responsibilities include but are not limited to:

Performing theoretical and computational research
Developing, implementing and maintaining scientific software
Participating in the organization of CCB and Flatiron-wide collaborative activities including seminars, workshops and meetings
Participating in the preparation of manuscripts for publication and of presentations at scientific conferences
Assisting in student mentorship
Sharing expertise and providing training and guidance to CCB staff and visitors as needed.

FRF positions are generally two-year appointments that can be renewed for a third year, contingent on performance. Fellows will be based, and have a principal office or workspace, at the Simons Foundation's offices in New York City. Fellows may also be eligible for subsidized housing within walking distance of the Flatiron Institute.

For more information about careers at the Flatiron Institute, please click here.

Qualifications

Education

Ph.D. in a relevant field (applied mathematics, statistics, computational biology, biophysics, computer science, engineering, mathematical physics, or related disciplines)

Related Skills & Other Requirements

Demonstrated abilities in mathematical modeling, analysis and/or scientific computation, scientific software and algorithm development, data analysis and inference, and image analysis
Ability to do original and outstanding research in computational biology, and expertise in computational methods, data analysis, software and algorithm development, modeling machine learning, and scientific simulation
Ability to work well in an interdisciplinary environment, and to collaborate with experimentalists
Strong oral and written communication, data documentation, and presentation skills

Compensation and Benefits

The full-time annual compensation for this position is $91,000.
In addition to competitive salaries, the Simons Foundation provides employees with an outstanding benefits package.

Application Instructions
To apply, please submit the following via the application portal:

Cover Letter, which should include a summary of applicants' most significant contributions in graduate school
Curriculum Vitae with publications list and, if relevant, links to software
Research Statement of no more than three (3) pages describing the applicant's past important results, current and future research interests which may include both scientific topics and algorithm and software development, and potential synergies with activities at CCB
Letters of Recommendation, at least two (2)

Applications for available positions that begin in 2026 will generally be reviewed beginning November 2025, and will be considered on a rolling basis until the positions are filled. For full consideration, candidates are strongly encouraged to submit their complete application by November 15, 2025.

SELECTION CRITERIA
Applications will be evaluated based on:

Past research accomplishments
The proposed research program
The synergy of applicant's expertise and research proposal topic with existing CCA staff and research programs, and potential to cross boundaries between CCB groups and/or the Flatiron Institute's other research centers.

Any queries about the application process or about CCB should be directed to ccbjobs@flatironinstitute.org. Queries about CCB may also be directed to scientific staff at CCB.

Our Commitment to Expanding Pathways to Science & Opportunities for All:
Many of the greatest ideas and discoveries come from a diverse mix of minds, backgrounds, and experiences. The Simons Foundation is committed to advancing basic science and mathematics to benefit humankind and expand our collective understanding of our world. As part of our mission, we support partners, programs, and initiatives that seek to broaden the scientific community and open pathways to science and mathematics careers.

The Simons Foundation provides equal opportunities to all applicants without regard to race, religion, color, age, sex, pregnancy, national origin, sexual orientation, gender identity, genetic disposition, neurodiversity, disability, veteran status, or any other protected category under federal, state, and local law.

To apply, please visit: https://apply.interfolio.com/173730

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Postal Mail:

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New York, New York 10010